For instance, with the support of partners such as UNAIDS, African countries have increased their domestic resources to respond to HIV by 150 percent in the last four years. In a bid to end HIV, TB and malaria as epidemics, increasing domestic finances for health is tremendously important. Increased domestic investments in health signal country ownership and are a pathway to real sustainability of programs. While seeking to catalyse domestic investments in health, the Global Fund partnership is supporting in-country innovations that increase domestic investments in health. Partnerships between UNITAID and Clinton Health Access Initiative (CHAI) are catalyzing innovative mechanisms for increased domestic investments in health. CHAI’s entrepreneurial approach to providing access to health care and UNITAID’s innovative financing mechanisms have emphasized creating partnerships and fostering strong country investments and ownership of programs. The Global Fund has found an effective way to stimulate domestic investments in health. It starts with the conviction that making a transformational difference in the lives of the millions of people affected by diseases in low- and middle income countries will require significantly bigger domestic investments in health – private and public.